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Procoagulant effect of adapalene in <t>TGA.</t> (A) Two-dimensional structure of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalen-2-carboxylic acid). (B) TGA performed on the <t>ST</t> <t>Genesia</t> platform with STG-Bleedscreen reagent in commercial plasma from a patient with severe HA. FVIII denotes plasma-derived FVIII (Factane; LFB). HA plasma was spiked with adapalene (50μM) in 0.4% DMSO (final concentration). The values of the TG variables (lag time, time to peak, peak height, and endogenous thrombin potential) for a representative TGA among the 3 replicates are given in . Adap, adapalene; NPP, normal pool plasma.
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Procoagulant effect of adapalene in <t>TGA.</t> (A) Two-dimensional structure of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalen-2-carboxylic acid). (B) TGA performed on the <t>ST</t> <t>Genesia</t> platform with STG-Bleedscreen reagent in commercial plasma from a patient with severe HA. FVIII denotes plasma-derived FVIII (Factane; LFB). HA plasma was spiked with adapalene (50μM) in 0.4% DMSO (final concentration). The values of the TG variables (lag time, time to peak, peak height, and endogenous thrombin potential) for a representative TGA among the 3 replicates are given in . Adap, adapalene; NPP, normal pool plasma.
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Procoagulant effect of adapalene in TGA. (A) Two-dimensional structure of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalen-2-carboxylic acid). (B) TGA performed on the ST Genesia platform with STG-Bleedscreen reagent in commercial plasma from a patient with severe HA. FVIII denotes plasma-derived FVIII (Factane; LFB). HA plasma was spiked with adapalene (50μM) in 0.4% DMSO (final concentration). The values of the TG variables (lag time, time to peak, peak height, and endogenous thrombin potential) for a representative TGA among the 3 replicates are given in . Adap, adapalene; NPP, normal pool plasma.

Journal: Blood Vessels, Thrombosis & Hemostasis

Article Title: Screening chemical libraries for the development of oral treatments for bleeding disorders ∗

doi: 10.1016/j.bvth.2026.100139

Figure Lengend Snippet: Procoagulant effect of adapalene in TGA. (A) Two-dimensional structure of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalen-2-carboxylic acid). (B) TGA performed on the ST Genesia platform with STG-Bleedscreen reagent in commercial plasma from a patient with severe HA. FVIII denotes plasma-derived FVIII (Factane; LFB). HA plasma was spiked with adapalene (50μM) in 0.4% DMSO (final concentration). The values of the TG variables (lag time, time to peak, peak height, and endogenous thrombin potential) for a representative TGA among the 3 replicates are given in . Adap, adapalene; NPP, normal pool plasma.

Article Snippet: This sensitive primary screen allowed us to quickly select 60 chemical compounds that were then submitted to a secondary screen consisting of a TGA on a ST Genesia platform (Diagnostica Stago) with STG-Bleedscreen reagent.

Techniques: Clinical Proteomics, Derivative Assay, Concentration Assay